Biography
I am British Heart Foundation Professor of Cardiovascular Medicine and a Consultant Cardiologist at Central Manchester University Hospitals NHS Trust. I joined The University of Manchester in April 2013 as Director of the Institute of Cardiovascular Sciences. I was a preclinical student at the University of St. Andrews and qualified in medicine from Oxford in 1988. Following junior clinical posts, I was an MRC Clinical Research Training Fellow in the Nuffield Department of Medicine at Oxford from 1993 to 1996. I completed training in clinical cardiology and set up my own scientific group in the Department of Cardiovascular Medicine at Oxford 1997-2000 under the mentorship of Hugh Watkins. In 2001 I moved to a Senior Lectureship at Newcastle University, where I founded the Molecular Cardiovascular Research Group. I led the group 2001-2012 as it grew from one PI to nine (including five Chairs and three Programme Grants). I was awarded a BHF Personal Chair in 2008. I have been an active clinical cardiologist throughout my scientific career. Between 2001 and 2013 I practiced as a Consultant Interventional Cardiologist; during most of this time my personal procedure volumes were in the top 10% of all operators nationally. Presently, my clinical focus is on inherited cardiovascular diseases where I am part of an integrated service for affected patients and their families provided with colleagues in Clinical Cardiology and the Manchester Centre for Genomic Medicine.
Research Interest
My main research interest is in the genetics of complex cardiovascular diseases. Among contributions my colleagues and I have made to this field are: the first demonstration of limited haplotype diversity over long distances in the human genome (1996); the first success in trans-ethnic fine mapping of a complex genetic trait in man (1998); the first large-scale genetic studies of myocardial infarction (2000-2004); the introduction of the approach known as “Mendelian Randomisation†into genetic epidemiology (2001); several large-scale meta-analyses of genetic associations with myocardial infarction (2005-2008); demonstration of the mechanism involved in the association between MI and its strongest common genetic risk factor (polymorphisms at CDKN2B-AS1 [2010]); demonstration of association between copy number variants in the human genome and sporadic congenital heart disease (2012) and the first published genome-wide association studies of congenital heart disease (2013). My group are now chiefly interested in understanding the functional biology underlying some of the many genetic associations with complex cardiovascular diseases that have been detected in genome-wide association studies (including our own work), and using next-generation sequencing approaches to further define the genetic architecture of congenital heart disease.
Biography
Paolo Manunta is Director of the Genetics of Kidney Diseases and Hypertension Unit, in the Division of Genetic and cellular Biology in San Raffaele Scientific Institute, Milan, Italy and he is also the Director of the Research Programs of the Nephrology and Dialysis Unit in San Raffaele Milan, Italy. He is the Co-chief of the Division of Nephrology and Dialysis of San Raffaele Scientific Institute, Milan. Paolo Manunta is Director for School of Nephrology, in the Università Vita Salute San Raffaele, Milan, Italy and Director, Associate Professor, Chair of Nephrology, Università Vita Salute San Raffaele, Milan, Italy. He is the Editorial Board Member of Journal of Hypertension World and etc., and serves as a member of various associations European Hypertension Society. His research interest includes Nephro-vascular hypertension, Physiology and pharmacology of cardiovascular and renal system with particular reference to hypertension disease, Cellular physiology, membrane ion transports, cellular volume regulation, and cellular membrane biochemistry in essential and genetic hypertension etc.
Research Interest
Nephro-vascular hypertension, Cellular physiology, Cardiovascular complication of renal failure
Biography
Frank J. Veith, Professor of Surgery, NYU and the Cleveland Clinic and Liebig Chair in Vascular Surgery. Dr. Veith graduated from Cornell University Medical College with Honors before completing his surgical residency training at Peter Bent Brigham Hospital and Harvard Medical School. Thereafter, he achieved success with his pioneering work in experimental and clinical lung transplantation. In the 70s and 80s, his attention turned toward Vascular Surgery with an emphasis on lower extremity revascularization procedures, many of which he innovated. He was the first to advocate an aggressive approach to saving limbs threatened by arteriosclerosis and gangrene when most patients with this problem were being treated by a major amputation. He and his group were recognized as world leaders in this field and had more than 300 published articles related to it. In the early 1990s, Dr. Veith, long an advocate of endovascular treatments, became involved with endovascular grafts, using them for a variety of vascular lesions. Many of these procedures he and his associates performed were “firstsâ€. His group was the first to perform an endovascular graft repair of an AAA or EVAR in the US. They also performed the first EVAR for a ruptured AAA. In 1995 he was elected President of the Society for Vascular Surgery and was a major force promoting the endovascular treatment of many vascular diseases. Dr. Veith held positions as Chief of Vascular Surgery and Chairman of Surgery at Montefiore Hospital - Albert Einstein College of Medicine for many years. He was also The William J. von Liebig Chair in Vascular Surgery. In 2006, Dr. Veith was appointed to his present positions at New York University and the Cleveland Clinic. He has received numerous awards and honors as a leader, outstanding teacher and innovator in Vascular Surgery. He chairs the largest Vascular meeting, the VEITH symposium, held annually in New York City and now in its 43rd year. In 2010, Dr. Veith received the SVS Distinguished Lifetime Achievement Award. In 2013 an endowed chair, the Frank J. Veith Chair in Vascular and Endovascular Surgery, was established at Langone New York University Medical Center. In 2016 Dr. Veith will be honored to receive the ISET Lifetime Achievement Award.
Research Interest
vascular surgery General vascular surgery
